Defining Alcohol-Related Phenotypes in Humans
نویسندگان
چکیده
Laura Jean Bierut, M.D.; Nancy L. Saccone, Ph.D.; John P. Rice, Ph.D.; Alison Goate, D. Phil.; Tatiana Foroud, Ph.D.; Howard Edenberg, Ph.D.; Laura Almasy, Ph.D.; P. Michael Conneally, Ph.D.; Raymond Crowe, Ph.D.; Victor Hesselbrock, Ph.D.; T. K. Li, M.D.; John Nurnberger, Jr., M.D., Ph.D.; Bernice Porjesz, Ph.D.; Marc A. Schuckit, M.D.; Jay Tischfield, Ph.D.; Henri Begleiter, M.D.; and Theodore Reich, M.D.
منابع مشابه
Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism.
Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COGA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electro...
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Background: Studies have found that genomic variation in the gene SNCA, which encodes the protein a-synuclein, may contribute to the variation in alcohol consumption in an inbred rat model of alcohol preference. Studies in humans have provided support for an association between SNCA and craving for alcohol. Methods: To examine the role of this gene in alcohol dependence and related phenotypes, ...
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تاریخ انتشار 2002